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Archive for the ‘Life Extension’ Category

The recent Science Debate poll identified “Should the United States fund a “War on Aging?” as the #1 question the scientific community wants to ask presidential candidates, gathering 3 times as many votes as any other. Yet, it was not included among the “top questions” to “tackle” that the candidates were asked.

I support a full-on war on aging, as well as the Longevity Party,  but must wonder if this question is continually swept to the nether regions because the powers-that-be don’t believe the masses will find it that useful. In reality, it isn’t likely extreme longevity technology or the enhancements therein will be readily available and/or affordable to the masses — it will be another “have” vs. “have-not” issue, only this time it will involve life vs. death on a very real basis.

Another obvious reason is the religious fanatics believe their respective deities are the givers and takers of life, despite the fact they utilize every life extension tool available to them currently (diabetes treatment, bypass surgery, medications, etc.). Any religious person  with an iota of legitimacy to their belief  would be as opposed to extreme life extension as they are to other life-engendering research.

Both of these objections need to be effectively overcome, or at least rationalized in an open and available forum, to move the Longevity Party into the sphere of a party digestable by the masses, I think.

via Death has a great lobby in US – Wikinews, the free news source.

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UCLA researchers have discovered that a diet enriched with a popular omega-3 fatty acid and an ingredient in curry spice helps to preserve walking ability in rats that have experienced damage to their spinal cords.

The findings, published June 26 in the Journal of Neurosurgery: Spine, suggest that these dietary supplements help repair nerve cells and maintain neurological function after degenerative damage to the neck.

“Normal aging often narrows the spinal canal, putting pressure on the spinal cord and injuring tissue,” said principal investigator Dr. Langston Holly, associate professor of neurosurgery at the David Geffen School of Medicine at UCLA. “While surgery can relieve the pressure and prevent further injury, it can’t repair damage to the cells and nerve fibers. We wanted to explore whether dietary supplementation could help the spinal cord heal itself.”

The UCLA team studied two groups of rats with a condition that simulated cervical myelopathy — a progressive disorder that often occurs in people with spine-weakening conditions like rheumatoid arthritis and osteoporosis. Cervical myelopathy can lead to disabling neurological symptoms, such as difficulty walking, neck and arm pain, hand numbness, and weakness of the limbs. It’s the most common cause of spine-related walking problems in people over 55.

The first group of animals was fed rat chow that replicated a Western diet high in saturated fats and sugar. The second group consumed a standard diet supplemented with docosahexaenoic acid (DHA) and curcumin, a compound in the Indian curry spice turmeric. A third set of rats received a standard rat diet and served as a control group.

Why these supplements? DHA is an omega-3 fatty acid shown to repair damage to cell membranes. Curcumin is a strong antioxidant that previous studies have linked to tissue repair. Both reduce inflammation.

“The brain and spinal cord work together, and years of research demonstrate that supplements like DHA and curcumin can positively influence the brain,” said study co-author Fernando Gomez-Pinilla, a professor of neurosurgery at UCLA. “We suspected that what works in the brain may also work in the spinal cord. When we were unable to find good data to support our hypothesis, we decided to study it ourselves.”

The researchers recorded a baseline of the rats walking and re-examined the animals’ gait on a weekly basis. As early as three weeks, the rats eating the Western diet demonstrated measurable walking problems that worsened as the study progressed. Rats fed a diet enriched with DHA and curcumin walked significantly better than the first group even six weeks after the study’s start.

Next, the scientists examined the rats’ spinal cords to evaluate how diet affected their injury on a molecular level. They measured levels of three markers respectively linked to cell-membrane damage, neural repair and cellular communication.

The rats that ate the Western diet showed higher levels of the marker linked to cell-membrane damage. In contrast, the DHA and curcumin appeared to offset the injury’s effect in the second group, which displayed marker levels that were equivalent to the control group.

Levels of the markers linked to neural repair and cellular communication were significantly lower in the rats raised on the Western diet. Again, levels in the animals fed the supplemented diet appeared similar to those of the control group.

“DHA and curcumin appear to invoke several molecular mechanisms that preserved neurological function in the rats,” said Gomez-Pinilla. “This is an exciting first step toward understanding the role that diet plays in protecting the body from degenerative disease.”

“Our findings suggest that diet can help minimize disease-related changes and repair damage to the spinal cord,” Holly said. “We next want to look at other mechanisms involved in the cascade of events leading up to chronic spinal-cord injury. Our goal is to identify which stages will respond best to medical intervention and identify effective steps for slowing the disease process.”

Other co-authors included Dr. Donald Blaskiewicz, Aiguo Wu, Cameron Feng and Zhe Ying, all of UCLA. Their research was supported by grants from the National Institutes of Health (RO1 NS056413) and the Craig H. Neilsen Foundation.

via Curry spice, omega-3 fatty acid preserve walking ability following spinal-cord injury – UCLA Health and Medicine News.

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Overcoming Bias : Frozen Or Plastic Brain?.

This article, although somewhat poorly written, provides the basis for debate between plastination and cryo-preservation of one’s brain for the purpose of being revived at some future time. Links are provided, in the first paragraph, to connect the reader to several comment sections where fascinating conversations regarding the merits and flaws of both plastination and cryo-preservation methods for brains are being discussed.

Besides the flaws mentioned here, the issue of what will be necessary for full revivication remains unknown. The best case scenario is still a full brain upload, prior to the death of the individual.�

I’ve often envisioned charitable organizations of the future, who have been specially formed solely for protecting those brains and bodies which lay waiting for the momentous breakthrough the individuals had hoped for at the time of preservation.�

Assuming humans survive several more centuries, or even far into future millennia, it is likely that many of the cultural memes of today will have faded out and new, more rational memes will have replaced them. The mere fact that humans have survived that long would likely indicate this occurrence. In this scenario, ethical considerations will take precedence over financial ones. Selection of who is revived, and for what reasons, will be clearly defined.�

Whether choosing plastination or cryo-preservation, I can hope that humans of the future are wiser and more ethical than we, and will screen out revivication candidates based on other ethical considerations. If someone with known psychopathy, like Dick Cheney, for example, is preserved, then revivifaction shouldn’t occur under any circumstances, unless a cure for psychopathy has come about, or perhaps special accommodations are made available for those with issues of this sort.

Another scenario is that humans of the future will most likely have reached a point of deliberate population limitations, which will, necessarily, severely impact revivication prospects for most of those who are preserved. If we assume the humans of the future have gained wisdom, insight and ethical understandings that we are still, today, struggling towards, then they may not wish to revive those from our era, unless they are those most apt to adapt and contribute to the current (future) cultural norms. �If this assumption is correct, then revivication order, or rights, will be based on those who can contribute most greatly, rather than those who can afford to purchase their place at the front of the line. For example, why should someone with large caches of money and political clout be revivified instead of someone with specific altruistic understandings and capabilities?�

 

via Overcoming Bias : Frozen Or Plastic Brain?.

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